Tocris型号参数规格 Tocris Bioscience批发，产品货源,Tocris/(±)-AMG 487/4487/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/(±)-AMG 487/4487/10/10 mg

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Tocris

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4487/10

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4000-520-616

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Description:CXCR3antagoNIST;inhibitscellmigrationandmetastasis

ChemicalName:N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AntagonistofCXCR3;inhibitsbindingof¹²⁵I-IP-10and¹²⁵I-ITACtoCXCR3(IC₅₀valuesare8.0and8.2nMrespectively).InhibitsCXCR3-mediatedcellmigrationbythechemokinesIP-10,ITACandMiGinvitro(IC₅₀valuesare8,15and36nMrespectively).Alsoshowntoinhibitlungmetastasisinamousemodelofmetastaticbreastcancer.

CompoundLibraries

(±)-AMG487isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	603.59
Formula	C₃₂H₂₈F₃N₅O₄
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	947536-03-0
PubChemID	10282265
InChIKey	WQTKNBPCJKRYPA-UHFFFAOYSA-N
Smiles	CCOC(C=C3)=CC=C3N2C(C1=CC=CN=C1N=C2C(N(CC4=CC=CN=C4)C(CC5=CC=C(OC(F)(F)F)C=C5)=O)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	60.36	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight603.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.66mL	8.28mL	16.57mL
5mM	0.33mL	1.66mL	3.31mL
10mM	0.17mL	0.83mL	1.66mL
50mM	0.03mL	0.17mL	0.33mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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