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Description:CXCR3antagoNIST;inhibitscellmigrationandmetastasis
ChemicalName:N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
AntagonistofCXCR3;inhibitsbindingof125I-IP-10and125I-ITACtoCXCR3(IC50valuesare8.0and8.2nMrespectively).InhibitsCXCR3-mediatedcellmigrationbythechemokinesIP-10,ITACandMiGinvitro(IC50valuesare8,15and36nMrespectively).Alsoshowntoinhibitlungmetastasisinamousemodelofmetastaticbreastcancer.
CompoundLibraries
(±)-AMG487isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 603.59 |
Formula | C32H28F3N5O4 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 947536-03-0 |
PubChemID | 10282265 |
InChIKey | WQTKNBPCJKRYPA-UHFFFAOYSA-N |
Smiles | CCOC(C=C3)=CC=C3N2C(C1=CC=CN=C1N=C2C(N(CC4=CC=CN=C4)C(CC5=CC=C(OC(F)(F)F)C=C5)=O)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 60.36 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight603.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.66mL | 8.28mL | 16.57mL |
5mM | 0.33mL | 1.66mL | 3.31mL |
10mM | 0.17mL | 0.83mL | 1.66mL |
50mM | 0.03mL | 0.17mL | 0.33mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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