Tocris厂家直采，平行进口 Tocris Bioscience产品促销,Tocris/AMG 853/5701/10/10 mg,受体,生物分子,生化试剂,,Tocris Bioscience蚂蚁淘商城

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Tocris/AMG 853/5701/10/10 mg

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Tocris

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5701/10

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Description:PotentdualCRTH2andprostaglandinD₂(PGD₂)receptorantagoNIST

ChemicalName:5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneaceticacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentdualCRTH2andprostaglandinD₂(PGD₂)receptorantagonist(IC₅₀valuesare8and35nM,respectivelyinplasma).InhibitsPGD₂-induceddownmodulationofCRTH2onCD16^-granulocytesinhumanwholebloodaswellasPGD₂-inducedcAMPresponseinplatelets.InhibitsPGD₂-inducedairwayconstrictioninvivo.AlsoinhibitsBRD4(K_d=170nM).Orallybioavailable.

TechnicalData

M.Wt	609.49
Formula	C₂₈H₂₇Cl₂FN₂O₆S
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1169483-24-2
PubChemID	42641863
InChIKey	PFWVGKROPKKEDW-UHFFFAOYSA-N
Smiles	ClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	60.95	100
	ethanol	60.95	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight609.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.64mL	8.2mL	16.41mL
5mM	0.33mL	1.64mL	3.28mL
10mM	0.16mL	0.82mL	1.64mL
50mM	0.03mL	0.16mL	0.33mL

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