BiologicalActivity
Selectiveinhibitorofmastcelltryptase(Ki=7.1μM)thatinhibitstryptase-inducedhistaminereleasefromhumantonsilandlungcells.Reducesairwayinflammationandblockspostchallengeairwayhyperresponsivenessinvivo.
TechnicalData
| M.Wt | 440.5 |
| Formula | C22H28N6O4 |
| Sequence | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
| Storage | Storeat-20°C |
| CASNumber | 158921-85-8 |
| PubChemID | 177340 |
| InChIKey | SKYWIMYOGAWOMB-IRXDYDNUSA-N |
| Smiles | OC2=C(C(N[C@@H](CCCNC(N)=N)C(N3[C@H]([C@](N)=O)CCC3)=O)=O)C=CC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto5mg/mlin20%ethanol/water |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight440.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.27mL | 11.35mL | 22.7mL |
| 5mM | 0.45mL | 2.27mL | 4.54mL |
| 10mM | 0.23mL | 1.14mL | 2.27mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
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