BiologicalActivity
AhighlyselectiveandrelativelypotentgroupIImetabotropicglutamatereceptoragonist.EC50valuesare0.4,0.4,>100,>100,>300and>300μMforhumanmGlu2,mGlu3,mGlu1,mGlu5,mGlu4andmGlu7receptorsrespectively.Centrallyactivefollowingsystemicadministrationinvivo.AlsoavailableaspartoftheGroupIImGluReceptorTocriset™.
LicensingInformation
SoldwiththepermissionofEliLillyandCompany
TechnicalData
| M.Wt | 174.16 |
| Formula | C6H10N2O4 |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 169209-63-6 |
| PubChemID | 5310984 |
| InChIKey | XZFMJVJDSYRWDQ-AWFVSMACSA-N |
| Smiles | N[C@]1([C@](O)=O)C[C@H]([C@](O)=O)NC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight174.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.74mL | 28.71mL | 57.42mL |
| 5mM | 1.15mL | 5.74mL | 11.48mL |
| 10mM | 0.57mL | 2.87mL | 5.74mL |
| 50mM | 0.11mL | 0.57mL | 1.15mL |
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