BiologicalActivity
RigidifiedanalogofMPPG(Cat.No.0853);selectivegroupIImetabotropicglutamatereceptorantagonist(IC50=30μM)withnosignificanteffectongroupIandIIImGlureceptorsatconcentrationsupto1mM.Increasesextracellularglutamateconcentrationsandpossessesunusualinverseagonist-likeaction.
TechnicalData
| M.Wt | 257.18 |
| Formula | C10H12NO5P |
| Storage | Desiccateat+4°C |
| CASNumber | 170847-18-4 |
| PubChemID | 4694355 |
| InChIKey | ZNQZXIHSJUDIKL-UHFFFAOYSA-N |
| Smiles | NC2(C(O)=O)CCC1=CC(P(O)(O)=O)=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto100mMin1.1eq.NaOH |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight257.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.89mL | 19.44mL | 38.88mL |
| 5mM | 0.78mL | 3.89mL | 7.78mL |
| 10mM | 0.39mL | 1.94mL | 3.89mL |
| 50mM | 0.08mL | 0.39mL | 0.78mL |
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