BiologicalActivity
Highaffinity,selectivemuscarinicM2receptorantagonist(pKivaluesare8.3,7.7and6.82forM2,M1andM3receptors,respectively).Displayscardioselectivityinvivo,overintestinal,trachealandbladdermuscarinicreceptors;inhibitsvagallyandagonist-inducedbradycardia.
CompoundLibraries
AQ-RA741isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 463.62 |
| Formula | C27H37N5O2 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 123548-16-3 |
| PubChemID | 129989 |
| InChIKey | BCUGCHZRMKTPMU-UHFFFAOYSA-N |
| Smiles | CCN(CC)CCCCC1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 46.36 | 100 | |
| DMSO | 46.36 | 100 | |
| ethanol | 46.36 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight463.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.16mL | 10.78mL | 21.57mL |
| 5mM | 0.43mL | 2.16mL | 4.31mL |
| 10mM | 0.22mL | 1.08mL | 2.16mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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