BiologicalActivity
Selective,competitiveP2Y2receptorantagonist.Inactiveagainstapanelof37otherreceptorsataconcentrationof10μM.InhibitsATP-γS-inducedmucinsecretioninbronchialepithelialcells(IC50=1μM).InhibitsP2Y2receptor-inducedβ-arrestintranslocationinvitro(pA2=37.2-51.3nM).
TechnicalData
| M.Wt | 537.59 |
| Formula | C28H23N7O3S |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 216657-60-2 |
| PubChemID | 54210200 |
| InChIKey | PVKNPGQAFNALOI-UHFFFAOYSA-N |
| Smiles | CC(C=C1)=CC2=C1C(C3=CN(CC4=CC=C(C(NC5=NN=NN5)=O)O4)C(NC3=S)=O)C(C=CC(C)=C6)=C6C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.76 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight537.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.86mL | 9.3mL | 18.6mL |
| 5mM | 0.37mL | 1.86mL | 3.72mL |
| 10mM | 0.19mL | 0.93mL | 1.86mL |
| 50mM | 0.04mL | 0.19mL | 0.37mL |
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