BiologicalActivity
PotentCXCR2antagonist(IC50=1nM);attenuatesoxaliplatin-inducedNF-κBactivation,increasesoxaliplatincytotoxicity,andpotentiatesoxaliplatin-inducedapoptosisinAIPCcells.Reducesthenumbersofneutrophilsinfiltratingintotumorsinbothinvitroandinvivomodelsanddelayedtumorgrowth.Orallybioavailable.
CompoundLibraries
AZ10397767isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 400.88 |
| Formula | C15H14ClFN4O2S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 333742-63-5 |
| PubChemID | 11858154 |
| InChIKey | KHTUORKUWBDRBX-SSDOTTSWSA-N |
| Smiles | C[C@@H](NC1=C2SC(NC2=NC(SCC3=C(C(Cl)=CC=C3)F)=N1)=O)CO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.09 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight400.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.49mL | 12.47mL | 24.95mL |
| 5mM | 0.5mL | 2.49mL | 4.99mL |
| 10mM | 0.25mL | 1.25mL | 2.49mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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