Tocris授权代理商，正品 Tocris神经传递素,Tocris/(±)-Bay K 8644/1544/10/10 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/(±)-Bay K 8644/1544/10/10 mg

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Tocris

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1544/10

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Description:Ca²⁺channelactivator(L-type)

ChemicalName:1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylicacid,methylester

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

L-typeCa²⁺channelactivator(EC₅₀=17.3nM).Haspositiveinotropic,vasoconstrictiveandbehavioraleffectsinvivo.Separateenantiomers(R)-(+)-BayK8644and(S)-(-)-BayK8644alsoavailable(Cat.Nos.1545and1546respectively).IncombinationwithBIX-01294(Cat.No.3364),helpsgenerateinducedpluripotentstemcells(iPSCs)frommouseembryonicfibroblasts(MEFs).Inhibitsautophagy.

CompoundLibraries

(±)-BayK8644isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	356.3
Formula	C₁₆H₁₅F₃N₂O₄
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	71145-03-4
PubChemID	2303
InChIKey	ZFLWDHHVRRZMEI-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1C(F)(F)F)[N+]([O-])=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	35.63	100
	ethanol	35.63	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight356.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.81mL	14.03mL	28.07mL
5mM	0.56mL	2.81mL	5.61mL
10mM	0.28mL	1.4mL	2.81mL
50mM	0.06mL	0.28mL	0.56mL

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