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Description:InhibitorofIL-1βpost-translationalprocessing;indirectlyinhibitsNLRP3
ChemicalName:N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofIL-1βpost-translationalprocessing(IC50=210nM).InhibitstheformationofmatureIL-1β.IndirectlyinhibitsNLRP3.Activeinvivoandorallybioavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
M.Wt | 452.99 |
Formula | C22H29ClN2O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 210825-31-3 |
PubChemID | 9911728 |
InChIKey | YRSBLSHMKVQWHP-UHFFFAOYSA-N |
Smiles | O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 45.3 | 100 | |
ethanol | 45.3 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight452.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.21mL | 11.04mL | 22.08mL |
5mM | 0.44mL | 2.21mL | 4.42mL |
10mM | 0.22mL | 1.1mL | 2.21mL |
50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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