Tocris GPCR ligands Tocris配体,Tocris/CP 424174/6107/50/50 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/CP 424174/6107/50/50 mg

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Tocris

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6107/50

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4000-520-616

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Description:InhibitorofIL-1βpost-translationalprocessing;indirectlyinhibitsNLRP3

ChemicalName:N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofIL-1βpost-translationalprocessing(IC₅₀=210nM).InhibitstheformationofmatureIL-1β.IndirectlyinhibitsNLRP3.Activeinvivoandorallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	452.99
Formula	C₂₂H₂₉ClN₂O₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	210825-31-3
PubChemID	9911728
InChIKey	YRSBLSHMKVQWHP-UHFFFAOYSA-N
Smiles	O=S(C1=CC(C(O)(C)C)=CC=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	45.3	100
	ethanol	45.3	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight452.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.21mL	11.04mL	22.08mL
5mM	0.44mL	2.21mL	4.42mL
10mM	0.22mL	1.1mL	2.21mL
50mM	0.04mL	0.22mL	0.44mL

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