Tocris经销商/代理商 Tocris离子通道调控剂,Tocris/CP 465022 hydrochloride/2932/10/10 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/CP 465022 hydrochloride/2932/10/10 mg

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Tocris/CP 465022 hydrochloride/2932/10/10 mg

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Tocris

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2932/10

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Description:Selective,non-competitiveAMPAantagoNIST

ChemicalName:3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinonehydrochloride

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,non-competitiveAMPAantagonist(IC₅₀=25nMinratcorticalneurons)thatdisplayspotentanticonvulsantactivity.AlsosignificantlyblocksthepersistentcomponentofNa_v1.6channelactivity.Brainpenetrantandorallyactive.

TechnicalData

M.Wt	499.41
Formula	C₂₆H₂₄ClFN₄O.HCl
Storage	DesiccateatRT
Purity	≥99%(HPLC)
CASNumber	199655-36-2
PubChemID	53251536
InChIKey	YKYDGCRJPYLXHY-GVYCEHEKSA-N
Smiles	O=C2N(C3=CC=CC=C3Cl)C(/C=C/C4=NC(CN(CC)CC)=CC=C4)=NC1=CC=C(F)C=C12.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	49.94	100
	water	4.99	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight499.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2mL	10.01mL	20.02mL
5mM	0.4mL	2mL	4mL
10mM	0.2mL	1mL	2mL
50mM	0.04mL	0.2mL	0.4mL

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BiologicalActivity

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