Tocris抗体品牌 Tocris GPCR ligands,Tocris/BIBU 1361 dihydrochloride/2417/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/BIBU 1361 dihydrochloride/2417/10/10 mg

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Tocris/BIBU 1361 dihydrochloride/2417/10/10 mg

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Tocris

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2417/10

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4000-520-616

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Description:SelectiveinhibitorofEGFR-kinase

ChemicalName:N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofepidermalgrowthfactorreceptor(EGFR)tyrosinekinase(IC₅₀=3nM).Displays~100-foldlowerpotencyagainstErbB2(IC₅₀=290nM)andisselectiveoverarangeofotherrelatedtyrosinekinases(IC₅₀>10μM).BlocksdownstreamEGFRsignalingeventssuchasMAPKK/MAPKactivation.OraladmiNISTrationinhibitsgrowthofestablishedhumanxenograftsinathymicmice.

CompoundLibraries

BIBU1361dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	516.87
Formula	C₂₂H₂₇ClFN₇.2HCl
Storage	Desiccateat+4°C
Purity	≥97%(HPLC)
CASNumber	793726-84-8
PubChemID	46861539
InChIKey	ZNNWCQCQUKAMGL-UHFFFAOYSA-N
Smiles	Cl.Cl.CCN(CC)CC1CCN(CC1)C1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	12.92	25
	ethanol	2.58	5
	water	51.69	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight516.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.93mL	9.67mL	19.35mL
5mM	0.39mL	1.93mL	3.87mL
10mM	0.19mL	0.97mL	1.93mL
50mM	0.04mL	0.19mL	0.39mL

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