BiologicalActivity
Potent,selectiveinhibitorofepidermalgrowthfactorreceptor(EGFR)tyrosinekinase(IC50=3nM).Displays>1000-foldlowerpotencyagainstErbB2(IC50=3.4μM)andarangeofotherrelatedtyrosinekinases(IC50>10μM).OraladmiNISTrationinhibitsgrowthofestablishedhumanxenograftsinathymicmice.
CompoundLibraries
BIBX1382dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 460.77 |
| Formula | C18H19ClFN7.2HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1216920-18-1 |
| PubChemID | 46861540 |
| InChIKey | RFXGEKWBTCMDAW-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CN1CCC(CC1)NC1=NC=C2N=CN=C(NC3=CC(Cl)=C(F)C=C3)C2=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.39 | 50 | |
| water | 19.39 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight460.77.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.85mL | 21.7mL |
| 5mM | 0.43mL | 2.17mL | 4.34mL |
| 10mM | 0.22mL | 1.09mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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