Tocris产品目录价格美国Tocris Bioscience公司,Tocris/BMS 536924/4774/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/BMS 536924/4774/10/10 mg

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Tocris

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4774/10

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4000-520-616

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Description:DualIR/IGF1Rinhibitor

ChemicalName:4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Dualinhibitoroftheinsulinreceptor(IR)andinsulin-likegrowthfactor-1receptor(IGF1R)(IC₅₀valuesare73and100nMrespectively).InhibitsreceptorautophosphorylationanddownstreamMEK1/2andAktsignaling.InducesG₁arrestandapoptosisinML-1cells;alsoinhibitscellproliferationinmultipletumortypes.ReversesEMTthroughtheattenuationofSnailmRNAexpressioninMCF10AcelloverexpressingIGF1R.

CompoundLibraries

BMS536924isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	479.96
Formula	C₂₅H₂₆ClN₅O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	468740-43-4
PubChemID	6077765
InChIKey	DXEATJQGQHDURZ-DEDYPNTBSA-N
Smiles	O=C1NC=CC(NC[C@H](C5=CC=CC(Cl)=C5)O)=C1C3=NC2=CC(N4CCOCC4)=CC(C)=C2N3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	48	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight479.96.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.08mL	10.42mL	20.84mL
5mM	0.42mL	2.08mL	4.17mL
10mM	0.21mL	1.04mL	2.08mL
50mM	0.04mL	0.21mL	0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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