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Tocris/BMS 599626 dihydrochloride/5022/10/10 mg

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Tocris/BMS 599626 dihydrochloride/5022/10/10 mg

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Tocris

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5022/10

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4000-520-616

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Description:Potent,selectiveEGFRandErbB2inhibitor

ChemicalName:(3S)-3-Morpholinylmethyl-[4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamatedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveEGFRandErbB2inhibitor(IC₅₀valuesare22nMand32nMrespectively).AlsoinhibitsHER4(IC₅₀=190nM).InhibitsEGFRandErbB2with100-foldgreaterpotencythanMEKandLck.Antiproliferativeagentinvitroandanti-tumOrigenicagentinvivo.Orallybioavailable.

CompoundLibraries

BMS599626dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	603.48
Formula	C₂₇H₂₇FN₈O₃.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	90488998
InChIKey	SKHKFWSXLCGMNF-IKXQUJFKSA-N
Smiles	FC1=CC(CN2N=CC3=C2C=CC(NC4=NC=NN5C4=C(C)C(NC(OC[C@@H]6COCCN6)=O)=C5)=C3)=CC=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	60.35	100
	water	3.02	5mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight603.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.66mL	8.29mL	16.57mL
5mM	0.33mL	1.66mL	3.31mL
10mM	0.17mL	0.83mL	1.66mL
50mM	0.03mL	0.17mL	0.33mL

ProductDatasheets

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