Tocris授权代理商，正品 Tocris信号通路抑制剂,Tocris/CHMFL-FLT3-122/5800/50/50 mg,激酶,Tocris,Bio-Techne,,50 mg蚂蚁淘商城

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Tocris/CHMFL-FLT3-122/5800/50/50 mg

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Tocris

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5800/50

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4000-520-616

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Description:PotentandselectiveFLT3inhibitor

ChemicalName:1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveFLT3inhibitor(IC₅₀=40nM).Exhibits>10-foldand170-foldselectivityforFLT3overBTKkinaseandc-KITkinase,respectivelyinvitro.InducesapoptosisbyarrestingcellcycleinG₀/G₁phaseinvitro.SuppressestumorgrowthinanAMLxenograftmodel.Modestlyorallybioavailable.

TechnicalData

M.Wt	471.55
Formula	C₂₆H₂₉N₇O₂
Storage	Storeat+4°C
CASNumber	1839150-56-9
PubChemID	121513893
InChIKey	IZNAFSDUTMZGSF-LJQANCHMSA-N
Smiles	NC1=C2C(N([C@@H]3CCCN(C(CN(C)C)=O)C3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	47.16	100
	DMSO	47.16	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight471.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.12mL	10.6mL	21.21mL
5mM	0.42mL	2.12mL	4.24mL
10mM	0.21mL	1.06mL	2.12mL
50mM	0.04mL	0.21mL	0.42mL

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