中国Tocris公司 Tocris Bioscience试剂产品信息,Tocris/CP 724714/5973/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/CP 724714/5973/50/50 mg

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Tocris

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5973/50

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4000-520-616

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Description:PotentandselectiveErbB2inhibitor

ChemicalName:2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveErbB2inhibitor(IC₅₀=10nM).Exhibits500-1000-foldselectivityforErbB2overErbB1andotherrelatedRTKs.InducesG₁cellcyclearrestinanErbB2-overexpressinghumancancercellline.Promotestumorapoptosis.Inducestumorregressioninahumantumorxenograftmodel.Displaysnoapparenttoxiceffectoncardiactissue.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofCP-724714isreviewedonthechemicalprobeswebsite.

TechnicalData

M.Wt	469.53
Formula	C₂₇H₂₇N₅O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	383432-38-0
PubChemID	9874913
InChIKey	LLVZBTWPGQVVLW-SNAWJCMRSA-N
Smiles	CC1=CC(NC2=NC=NC3=CC=C(/C=C/CNC(COC)=O)C=C32)=CC=C1OC4=CC=C(C)N=C4

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	46.95	100
	ethanol	46.95	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight469.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.13mL	10.65mL	21.3mL
5mM	0.43mL	2.13mL	4.26mL
10mM	0.21mL	1.06mL	2.13mL
50mM	0.04mL	0.21mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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