进口试剂Tocris直采进口Tocris Bioscience现货,Tocris/Canertinib dihydrochloride/5916/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/Canertinib dihydrochloride/5916/10/10 mg

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Tocris/Canertinib dihydrochloride/5916/10/10 mg

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Tocris

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5916/10

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4000-520-616

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Description:PotentEGFRkinaseinhibitor

AlternativeNames:CI1033,PD183805

ChemicalName:N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamidedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentEGFRkinaseinhibitor(IC₅₀=7.4nM).BlocksautophosphorylationoferbB2.InhibitsgrowthofA431tumorxenograftsinmice.Cellpermeable.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	558.86
Formula	C₂₄H₂₅ClFN₅O_3.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	289499-45-2
PubChemID	156413
InChIKey	JZZFDCXSFTVOJY-UHFFFAOYSA-N
Smiles	O=C(C=C)NC1=C(OCCCN4CCOCC4)C=C(N=CN=C2NC3=CC(Cl)=C(F)C=C3)C2=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	55.89	100
	water	11.18	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight558.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.79mL	8.95mL	17.89mL
5mM	0.36mL	1.79mL	3.58mL
10mM	0.18mL	0.89mL	1.79mL
50mM	0.04mL	0.18mL	0.36mL

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