Tocris公司代理生物计划 Tocris Bioscience批发，产品货源,Tocris/DDR1-IN-1 dihydrochloride/5077/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/DDR1-IN-1 dihydrochloride/5077/10/10 mg

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Tocris/DDR1-IN-1 dihydrochloride/5077/10/10 mg

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Tocris

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5077/10

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4000-520-616

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Description:SelectiveDDR1inhibitor

ChemicalName:N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamidedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectivediscoidindomainreceptor1(DDR1)tyrosinekinaseinhibitor(IC₅₀valuesare105and413nMforDDR1andDDR2respectively).Inhibitsintegrin-inducedDDR1autophosphorylationinanosteosarcomacellline.

ExternalPortalInformation

Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofDDR1-IN-1isreviewedonthechemicalprobeswebsite.

CompoundLibraries

DDR1-IN-1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	625.51
Formula	C₃₀H₃₁F₃N₄O₃.2HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
PubChemID	90489006
InChIKey	PBUOJKYQZINPKD-UHFFFAOYSA-N
Smiles	CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	31.28	50
	water	62.55	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight625.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.6mL	7.99mL	15.99mL
5mM	0.32mL	1.6mL	3.2mL
10mM	0.16mL	0.8mL	1.6mL
50mM	0.03mL	0.16mL	0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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