BiologicalActivity
ActivatorofChk2thatcausesG2/Mcellcyclearrestinvariouscancercelllines.Antiproliferativeandinducerofapoptosis;promotesproteasomaldegradationofCdc25CandCdk1.InhibitsphosphorylationofEGFRanddownstreamactivationofERK.
TechnicalData
| M.Wt | 246.31 |
| Formula | C17H14N2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1968-05-4 |
| PubChemID | 10900930 |
| InChIKey | SHXKYUYEFDONQC-UHFFFAOYSA-N |
| Smiles | C12=CC=CC=C1C(CC3=CC(C=CC=C4)=C4N3)=CN2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.63 | 100 | |
| ethanol | 12.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight246.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.06mL | 20.3mL | 40.6mL |
| 5mM | 0.81mL | 4.06mL | 8.12mL |
| 10mM | 0.41mL | 2.03mL | 4.06mL |
| 50mM | 0.08mL | 0.41mL | 0.81mL |
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