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Description:Potent,selectiveinhibitorofPDGFRβ
ChemicalName:5,7-Dimethoxy-3-(4-pyridinyl)quinolinedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Apotentandselectiveinhibitorofhumanvascularβ-typeplateletderivedgrowthfactorreceptortyrosinekinase(PDGFRβ)(IC50=80nM).Displays>100-foldselectivityoverEGFRtyrosinekinase,erbB2,p56,proteinkinaseAandproteinkinaseC.
TechnicalData
M.Wt | 339.22 |
Formula | C16H14N2O2.2HCl |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1123491-15-5 |
PubChemID | 45073427 |
InChIKey | YBBAOKYVJCNJIV-UHFFFAOYSA-N |
Smiles | COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solubility | Solubleto100mMinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight339.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.95mL | 14.74mL | 29.48mL |
5mM | 0.59mL | 2.95mL | 5.9mL |
10mM | 0.29mL | 1.47mL | 2.95mL |
50mM | 0.06mL | 0.29mL | 0.59mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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