BiologicalActivity
Selectiveinsulinreceptor(IR)activator(EC50valuesare3-6μMforIRTKand100μMforIGF1RandEGFR).IncreasesIRβsubunittyrosinephosphorylationandactivationofPI3-kinaseandAkt,butnotERK.Inducesglucoseuptakeinadipocytesandskeletalmuscleinvitro,withoutenhancingvascularproliferation.BindsGAPDH.AlsoactivatesTrkbyinteractingatasitedistinctfromtheneurotrophin-bindingsite.
TechnicalData
| M.Wt | 506.59 |
| Formula | C32H30N2O4 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 78860-34-1 |
| PubChemID | 3013166 |
| InChIKey | XMGNJVXBPZAETK-UHFFFAOYSA-N |
| Smiles | CC(C)=CCC1=C2NC=C(C2=CC=C1)C1=C(O)C(=O)C(C2=C(NC3=CC=CC=C23)C(C)(C)C=C)=C(O)C1=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.66 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight506.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.97mL | 9.87mL | 19.74mL |
| 5mM | 0.39mL | 1.97mL | 3.95mL |
| 10mM | 0.2mL | 0.99mL | 1.97mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |
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