BiologicalActivity
TyrosinekinasereceptorB(TrkB)agonistthatbindstotheextracellulardomainofthereceptor(Kd=320nM).Inhibitsglutamate-triggeredapoptosisinhippocampalneuronsinvitroandinvivo.ExhibitsneuroprotectiveeffectsinanHDmousemodel.
TechnicalData
| M.Wt | 254.24 |
| Formula | C15H10O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 38183-03-8 |
| PubChemID | 1880 |
| InChIKey | COCYGNDCWFKTMF-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=C(O)C(O)=C1OC(C3=CC=CC=C3)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 2eq.NaOH | 25.42 | 100 | |
| DMSO | 25.42 | 100 | |
| ethanol | 6.36 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight254.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.93mL | 19.67mL | 39.33mL |
| 5mM | 0.79mL | 3.93mL | 7.87mL |
| 10mM | 0.39mL | 1.97mL | 3.93mL |
| 50mM | 0.08mL | 0.39mL | 0.79mL |
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