BiologicalActivity
Neuropilin1(NRP1)receptorantagonist;inhibitsVEGFAbindingtotheNRP1b1domain.HasnoeffectonVEGFAbindingtoVEGFR-1andVEGFR-2.ReducesVEGFA-inducedVEGFR-2tyrosinephosphorylationinHUVECs.AlsoattenuatesVEGFA-inducedHUVECcellmigrationandreducesA549lungcarcinomacellviABIlityinvitro.Increaseschemo-sensitivityofA549cellsincombinationwithTaxol(Cat.No.1097).Blockspro-tumOrigenicM2polarizationinglioma-associatedmicrogliaandmacrophagesandreducestumorgrowthandvascularizationinNSGmice.
CompoundLibraries
EG00229isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 497.57 |
| Formula | C17H19N7O5S3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1018927-63-3 |
| PubChemID | 44631827 |
| InChIKey | ZWWMEDURALZMEV-NSHDSACASA-N |
| Smiles | O=S(C1=CC=CC2=NSN=C12)(NC3=C(C(N[C@H](C(O)=O)CCCNC(N)=N)=O)SC=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 49.76 | 100 | |
| DMSO | 49.76 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight497.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.01mL | 10.05mL | 20.1mL |
| 5mM | 0.4mL | 2.01mL | 4.02mL |
| 10mM | 0.2mL | 1mL | 2.01mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |
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