Tocris代理，产品目录 Tocris抗体,Tocris/GW 583340 dihydrochloride/2239/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

Tocris/GW 583340 dihydrochloride/2239/50/50 mg

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/GW 583340 dihydrochloride/2239/50/50 mg

品牌 /

Tocris

货号 /

2239/50

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:PotentdualEGFR/ErbB2inhibitor;orallyactive

ChemicalName:N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentdualEGFR/ErbB2tyrosinekinaseinhibitor(IC₅₀valuesare0.01and0.014μMrespectively).SelectivelyinhibitsgrowthofhumantumorcellsoverexpressingEGFRandErbB2(IC₅₀valuesare0.11μMforinhibitionofHN5,N87andBT474tumorcelllinesvs.>30μMforinhibitionofnon-tumorcelllineHFF).Inhibitstumorgrowthinvivoby~80%inamurinexenograftmodelfollowingoraladmiNISTration.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline.

CompoundLibraries

GW583340dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	671.03
Formula	C₂₈H₂₅ClFN₅O₃S₂.2HCl
Storage	Desiccateat+4°C
Purity	≥97%(HPLC)
CASNumber	1173023-85-2
PubChemID	16219404
InChIKey	WIMITXDBYLKRKB-UHFFFAOYSA-N
Smiles	Cl.Cl.CS(=O)(=O)CCNCC1=NC(=CS1)C1=CC=C2N=CN=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	67.1	100mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight671.03.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.49mL	7.45mL	14.9mL
5mM	0.3mL	1.49mL	2.98mL
10mM	0.15mL	0.75mL	1.49mL
50mM	0.03mL	0.15mL	0.3mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage: