BiologicalActivity
InhibitorofFMS-likereceptortyrosinekinase-3(FLT3)(IC50=15nM).DisplaysselectivityforFLT3against6otherkinasesincludingEGFR.DisplaysantiproliferativeactivityagainsttheMV4;11cellline(expressingconstitutivelyactiveFLT3)andanumberofcancercelllines,includingSNU-638(stomachcarcinoma)andHT-1080(fibrosarcoma).
LicensingInformation
SoldunderlicencefromAnygenCo.Ltd.
TechnicalData
| M.Wt | 295.27 |
| Formula | C16H10FN3O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 861214-33-7 |
| PubChemID | 11580208 |
| InChIKey | LBUXOYSDWHGJNP-UHFFFAOYSA-N |
| Smiles | O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight295.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.39mL | 16.93mL | 33.87mL |
| 5mM | 0.68mL | 3.39mL | 6.77mL |
| 10mM | 0.34mL | 1.69mL | 3.39mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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