Tocris经销商/代理商 Tocris离子通道调控剂,Tocris/GNF 5837/4559/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/GNF 5837/4559/50/50 mg

品牌 /

Tocris

货号 /

4559/50

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:PotentTrkinhibitor;inhibitsTrkA,TrkBandTrkC

ChemicalName:N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentpan-Trkinhibitor.DisplaysantiproliferativeeffectsincellularBa/F3assays(IC₅₀valuesare7,9and11nMforcellscontainingthefusionproteinsTel-TrkC,Tel-TrkBandTel-TrkA,respectively).ExhibitsselectivityforTrkreceptorsoverarangeofkinases,withsomeactivityatPDGFRandc-Kit(IC₅₀valuesare0.87and0.91μMrespectively).Orallybioavailable.

CompoundLibraries

GNF5837isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	535.49
Formula	C₂₈H₂₁F₄N₅O₂
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1033769-28-6
PubChemID	59397065
InChIKey	YYDUWLSETXNJJT-MTJSOVHGSA-N
Smiles	O=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	53.55	100
	ethanol	5.35	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight535.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.87mL	9.34mL	18.67mL
5mM	0.37mL	1.87mL	3.73mL
10mM	0.19mL	0.93mL	1.87mL
50mM	0.04mL	0.19mL	0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage:

BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

MolarityCalculator

ReconstitutionCalculator

DilutionCalculator

ProductDatasheets