BiologicalActivity
Potent,selectiveinhibitorofclassIIIreceptortyrosinekinases(IC50valuesare0.3μMforc-Fms,c-Kit,FLT3andITD-FLT3and1μMforPDGFRβ).DisplaysnoactivityagainstERK1,ERK2,EGFR,MEK1,HER2,Src,Abl,PKC,PKAandAkt(IC50>10μM).InhibitsFL-dependentproliferationinBaF/ITD-FLT3cellsmorepotentlythanBaF/wt-FLT3cells;anti-leukemic.
CompoundLibraries
GTP14564isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 234.26 |
| Formula | C15H10N2O |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 34823-86-4 |
| PubChemID | 3385203 |
| InChIKey | DZQLVVLATXPWBK-UHFFFAOYSA-N |
| Smiles | N1N=C(C2=C1C1=C(O2)C=CC=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.43 | 100 | |
| ethanol | 5.86 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight234.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.27mL | 21.34mL | 42.69mL |
| 5mM | 0.85mL | 4.27mL | 8.54mL |
| 10mM | 0.43mL | 2.13mL | 4.27mL |
| 50mM | 0.09mL | 0.43mL | 0.85mL |
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