BiologicalActivity
PotentandselectivecFMSkinaseinhibitor(IC50=0.06μM).ExhibitsselectivityforcFMSkinaseover186otherkinases.InhibitsCSF-1-inducedgrowthofratmonocytesinvitro.Alsoinhibitsboneresorptioninosteoclastcultures,aswellasconnectivetissueandbonedestructioninaratadjuvantarthritismodel.SuppressesM-NFS-60tumorcellgrowthinmice.Orallybioavailable.
TechnicalData
| M.Wt | 366.41 |
| Formula | C20H22N4O3 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 870483-87-7 |
| PubChemID | 11617559 |
| InChIKey | MYQAUKPBNJWPIE-UHFFFAOYSA-N |
| Smiles | NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.32 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight366.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.73mL | 13.65mL | 27.29mL |
| 5mM | 0.55mL | 2.73mL | 5.46mL |
| 10mM | 0.27mL | 1.36mL | 2.73mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |
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