生命科学Tocris价格优惠 Tocris化合物筛选文库,Tocris/HDS 029/2646/1/1 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/HDS 029/2646/1/1 mg

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Tocris

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2646/1

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4000-520-616

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Description:PotentinhibitoroftheErbBreceptorfamily

ChemicalName:N-(4-[(-3-Chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitoroftheErbBreceptorfamily(IC₅₀valuesare0.3,0.5and1.1nMforErbB1(EGFR),ErbB4andErbB2respectively).InhibitsEGF-inducederbB1autophosphorylationinNIH3T3cellsandheregulin-stimulatedErbBautophosphorylationinMDA-MB-453humanbreastcarcinomacells(IC₅₀valuesare2.5and24nMrespectively).

TechnicalData

M.Wt	355.76
Formula	C₁₇H₁₁ClFN₅O
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	881001-19-0
PubChemID	11566580
InChIKey	DLPSDPPZXRJQOY-UHFFFAOYSA-N
Smiles	FC(C=C3)=C(Cl)C=C3NC1=NC=NC2=C1C=C(NC(C#CC)=O)N=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	8.89	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight355.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.81mL	14.05mL	28.11mL
5mM	0.56mL	2.81mL	5.62mL
10mM	0.28mL	1.41mL	2.81mL
50mM	0.06mL	0.28mL	0.56mL

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