请使用支持JavaScript的浏览器! 正品Tocris生物试剂1 Tocris Bioscience型号参数规格,Tocris/HKI 357/3580/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城
商品信息
联系客服
Tocris/HKI 357/3580/50/50 mg
郑重提醒:
无质量问题不接受退换货,下单前请仔细核对信息。
下单后请及时联系客服核对商品价格,订单生效后再付款。
Tocris/HKI 357/3580/50/50 mg
品牌 / 
Tocris
货号 / 
3580/50
美元价:
(友情提示:该价格仅为参考,欢迎联系客服询价!)
数    量:
免费咨询热线
4000-520-616
Description:DualirreversIBLeinhibitorofErbB2andEGFR
ChemicalName:(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,irreversibleinhibitorofErbB2(HER2)andEGFR(IC50valuesare33and34nMrespectively).Suppressesligand-inducedEGFRautophosphorylationandcellproliferationinNCI-H1975cellscontainingL858RandT790Mmutations.CircumventsmechanismsofresistancetoIressa(Cat.No.3000)innon-small-celllungcancercells.

CompoundLibraries

HKI357isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt574.05
FormulaC31H29ClFN5O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber848133-17-5
PubChemID11238512
InChIKeyNERXPXBELDBEPZ-RMKNXTFCSA-N
SmilesO=C(/C=C/CN(C)C)NC1=C(OCC)C=C(N=CC(C#N)=C2NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO57.4100
ethanol14.3525

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight574.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.74mL8.71mL17.42mL
5mM0.35mL1.74mL3.48mL
10mM0.17mL0.87mL1.74mL
50mM0.03mL0.17mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet