BiologicalActivity
Orallyactive,selectiveinhibitorofEGFRtyrosinekinase(IC50=23-79nM).ShowsminimalactivityagainstErbB2,KDR,c-flt,PKC,MEKandERK-2.BlocksEGFRautophosphorylationandinhibitstumorgrowthinmicebearingarangeofhumanxenografts.
ViewinformationregardingtheusageofIressafornon-clinicalstudies.
LicensingInformation
SoldforresearchpurposesonlyunderagreementfromAstraZeneca
CompoundLibraries
IressaisalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 446.9 |
| Formula | C22H24ClFN4O3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 184475-35-2 |
| PubChemID | 123631 |
| InChIKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=C(Cl)C=C3NC2=NC=NC1=CC(OC)=C(OCCCN4CCOCC4)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.69 | 100 | |
| ethanol | 4.47 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight446.9.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.24mL | 11.19mL | 22.38mL |
| 5mM | 0.45mL | 2.24mL | 4.48mL |
| 10mM | 0.22mL | 1.12mL | 2.24mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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