BiologicalActivity
PotentandselectiveErbBreceptorfamilyinhibitor(IC50valuesare21,22and38nMforErbB4,EGFRandErbB2respectively).DisplayspotentgrowthinhibitionofhumancancercelllinesoverexpressingErbB2invitro(IC50=60-168nM)andinhibitsgrowthofhumantumorxenograftsinvivo.Brainpenetrantandorallyactive.
TechnicalData
| M.Wt | 519.42 |
| Formula | C24H27ClN6O3.HCl |
| Storage | Desiccateat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 944342-90-9 |
| PubChemID | 17747413 |
| InChIKey | ZXKZRKQMKNRZNN-GZPZNDDGSA-N |
| Smiles | NC1=C(/C=N/OCCN2CCOCC2)C(NC3=CC(Cl)=C(OCC4=CC=CC=C4)C=C3)=NC=N1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.97 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight519.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.93mL | 9.63mL | 19.25mL |
| 5mM | 0.39mL | 1.93mL | 3.85mL |
| 10mM | 0.19mL | 0.96mL | 1.93mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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