进口Tocris品牌清关代理 Tocris小分子,Tocris/KRCA 0008/5098/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/KRCA 0008/5098/50/50 mg

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Tocris

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5098/50

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4000-520-616

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Description:PotentAck1andALKdualinhibitor;orallybioavailable

ChemicalName:1,1'-[(5-Chloro-2,4-pyrimidinediyl)bis[imino(3-methoxy-4,1-phenylene)-4,1-piperazinediyl]]bisethanone

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentAck1andanaplasticlymphomakinase(ALK)dualinhibitor(IC₅₀valuesare4and12nMrespectively).InhibitslungcancerH3122cellproliferation(IC₅₀=80nM).AttenuatesH3122cellxenografttumorgrowthinmice.Orallybioavailable.

CompoundLibraries

KRCA0008isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	609.12
Formula	C₃₀H₃₇ClN₈O₄
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	1472795-20-2
PubChemID	72547474
InChIKey	TXDIRJCYNAWBOS-UHFFFAOYSA-N
Smiles	ClC1=C(NC2=C(OC)C=C(N3CCN(C(C)=O)CC3)C=C2)N=C(NC4=CC=C(N5CCN(C(C)=O)CC5)C=C4OC)N=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	60.91	100
	DMSO	60.91	100
	ethanol	60.91	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight609.12.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.64mL	8.21mL	16.42mL
5mM	0.33mL	1.64mL	3.28mL
10mM	0.16mL	0.82mL	1.64mL
50mM	0.03mL	0.16mL	0.33mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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PreparingStockSolutions

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