BiologicalActivity
Potenttropomyosin-relatedkinaseB(TrkB)agonist(IC50=47nM).InducesactivationofTrk,AktandERKinmousehippocampusandstriatum.Reversesdeficitsinmotortasklearninginmicefollowingtraumaticbraininjury;restoresrespiratoryfunctioninaratmodelofRettsyndrome.
CompoundLibraries
LM22A4isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 339.34 |
| Formula | C15H21N3O6 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 37988-18-4 |
| PubChemID | 2054170 |
| InChIKey | RGWJKANXFYJKHN-UHFFFAOYSA-N |
| Smiles | O=C(NCCO)C1=CC(C(NCCO)=O)=CC(C(NCCO)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.93 | 100 | |
| water | 33.93 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight339.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.95mL | 14.73mL | 29.47mL |
| 5mM | 0.59mL | 2.95mL | 5.89mL |
| 10mM | 0.29mL | 1.47mL | 2.95mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
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