BiologicalActivity
Nonpeptidep75NTRligand;blocksp75-mediatedcelldeathandalsoincreasesproliferationandsurvivalofhippocampalneuralProgenitors.Exhibitsnoeffectonnervegrowthfactor(NGF)bindingtoTrkA.Preventsandreversesatrophyofcholinergicneurites,aswellasreversingAlzheimer'sDisease(AD)pathologiesinmid-tolate-stageADmicemodels.Showntopromotefunctionalrecoveryinamousemodelofspinalcordinjury.Orallyavailableandbrainpenetrant.
TechnicalData
| M.Wt | 316.27 |
| Formula | C12H25N3O2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1243259-19-9 |
| PubChemID | 91654620 |
| InChIKey | LLIHJRRZJDEKLB-ULEGLUPFSA-N |
| Smiles | O=C([C@@H](N)[C@@H](C)CC)NCCN1CCOCC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.63 | 100 | |
| water | 31.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.81mL | 31.62mL |
| 5mM | 0.63mL | 3.16mL | 6.32mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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