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Tocris/NVP ADW 742/5247/50/50 mg

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Tocris

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5247/50

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4000-520-616

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Description:ATP-competitiveinhibitorofIGF1R

ChemicalName:5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ATP-competitiveinhibitorofIGF1R(IC₅₀intherangeof0.1-0.2μM).Alsoinhibitsc-Kitkinaseactivity(IC₅₀intherangeof3-5μM).ExhibitsasynergisticeffectwithImatinib,enhancingthesensitivityofmultiplesmallcelllungcancercelllinestothechemotherapeuticsetoposide(Cat.No.1226)andcarboplatin(Cat.No.2626).

CompoundLibraries

NVPADW742isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	453.58
Formula	C₂₈H₃₁N₅O
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	475488-23-4
PubChemID	9825149
InChIKey	LSFLAQVDISHMNB-UHFFFAOYSA-N
Smiles	NC1=NC=NC2=C1C(C4=CC(OCC5=CC=CC=C5)=CC=C4)=CN2[C@@H]3C[C@@H](CN6CCCC6)C3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	22.68	50
	ethanol	4.54	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight453.58.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.2mL	11.02mL	22.05mL
5mM	0.44mL	2.2mL	4.41mL
10mM	0.22mL	1.1mL	2.2mL
50mM	0.04mL	0.22mL	0.44mL

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BiologicalActivity

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