BiologicalActivity
SelectiveinhibitorofEphB4kinase;exhibitsselectivityforEphB4overmorethan40otherkinasesinvitro,includingFGFR3.InhibitsEphB4autophosphorylationintransientlytransfectedHEK293cells.AlsoinhibitsVEGF-inducedangiogenesisinvivo;thoughttoinhibitEphB4forwardsignaling.Orallyactive.
TechnicalData
| M.Wt | 617.5 |
| Formula | C26H20F3N7O.CF3CO2H |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 940310-85-0 |
| PubChemID | 73332408 |
| InChIKey | KCYJGZKWKFCVGC-UHFFFAOYSA-N |
| Smiles | CN1N=CC2=C1N=C(C4=CC=CN=C4)N=C2NC3=CC(C(NC5=CC=CC(C(F)(F)F)=C5)=O)=CC=C3C.OC(C(F)(F)F)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.7 | 40 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight617.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.62mL | 8.1mL | 16.19mL |
| 5mM | 0.32mL | 1.62mL | 3.24mL |
| 10mM | 0.16mL | 0.81mL | 1.62mL |
| 50mM | 0.03mL | 0.16mL | 0.32mL |
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