BiologicalActivity
AngiotensinIVanalog.HighlypotentHGF/c-METinhibitor(IC50=3pM).InhibitsHGF-inducedMDCKcellproliferationandinvasioninvitro.AlsoAT4receptorantagonist;disruptsLTPstABIlization.Antiangiogenic.
TechnicalData
| M.Wt | 774.95 |
| Formula | C41H58N8O7 |
| Sequence | XYLHPF (Modifications:X=Nle,Leu-3-His-4peptidebondreplacedwithCH2NH) |
| Storage | Storeat-20°C |
| CASNumber | 334994-34-2 |
| PubChemID | 91691127 |
| InChIKey | LOHDEFSMLITXTG-RZAPKHMUSA-N |
| Smiles | [H]N(C(CC1=CC=C(O)C=C1)C(=O)N[C@H](CN[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)CC(C)C)C(=O)[C@@H](N)CCCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto2mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight774.95.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.29mL | 6.45mL | 12.9mL |
| 5mM | 0.26mL | 1.29mL | 2.58mL |
| 10mM | 0.13mL | 0.65mL | 1.29mL |
| 50mM | 0.03mL | 0.13mL | 0.26mL |
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