BiologicalActivity
Anextremelypotentinhibitorofepidermalgrowthfactor(EGF)receptortyrosinekinase,withanIC50of25pM.Inhibitsotherpurifiedtyrosinekinasesonlyatmicromolarorhigherconcentrations.
LicensingInformation
SoldwiththepermissionofAstraZenecaUKLtd.
TechnicalData
| M.Wt | 396.67 |
| Formula | C16H14BrN3O2.HCl |
| Storage | StoreatRT |
| CASNumber | 183322-45-4 |
| PubChemID | 11246488 |
| InChIKey | ZJOKWAWPAPMNIM-UHFFFAOYSA-N |
| Smiles | BrC1=CC=CC(NC3=NC=NC2=CC(OC)=C(OC)C=C23)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.97 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight396.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.6mL | 25.21mL |
| 5mM | 0.5mL | 2.52mL | 5.04mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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