BiologicalActivity
PotentinhibitorofErbBreceptorfamilytyrosinekinases(IC50valuesare0.008,49and52nMforEGFR,ErbB2andErbB2/ErbB4respectively)thatdoesnotinhibitFGForPDGF-mediatedtyrosinephosphorylation.InducesG1cellcyclearrestinMCF10AcellsandisantiproliferativeinA431humanepidermalcarcinomacells.
CompoundLibraries
PD158780isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 330.18 |
| Formula | C14H12BrN5 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 171179-06-9 |
| PubChemID | 4707 |
| InChIKey | KFHMLBXBRCITHF-UHFFFAOYSA-N |
| Smiles | CNC1=NC=C2N=CN=C(NC3=CC=CC(Br)=C3)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.01 | 100 | |
| ethanol | 8.25 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight330.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.03mL | 15.14mL | 30.29mL |
| 5mM | 0.61mL | 3.03mL | 6.06mL |
| 10mM | 0.3mL | 1.51mL | 3.03mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
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