TocrisX中国代理价格，厂家 Tocris神经传递素,Tocris/PD 161570/3724/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PD 161570/3724/50/50 mg

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Tocris

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3724/50

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4000-520-616

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Description:SelectiveFGFRinhibitor

ChemicalName:N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveFGFRinhibitor(IC₅₀valuesare40,262and3700nMforFGFR,PDGFRandEGFRrespectively).InhibitsFGFRreceptorphosphorylation(IC₅₀=622nM)andgrowthofA121cellsinvitro.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PD161570isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	532.51
Formula	C₂₆H₃₅Cl₂N₇O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	192705-80-9
PubChemID	5328135
InChIKey	MKVMEJKNLUWFSQ-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(Cl)=C1C3=CC2=CN=C(NCCCCN(CC)CC)N=C2N=C3NC(NC(C)(C)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	53.25	100
	ethanol	53.25	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight532.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.88mL	9.39mL	18.78mL
5mM	0.38mL	1.88mL	3.76mL
10mM	0.19mL	0.94mL	1.88mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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