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Description:InhibitsNGFbindingtop75NTR
ChemicalName:7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
AnonpeptideinhibitorofNGFbindingtop75NTR(IC50~1μMinCHOcells);bindsNGF,notp75NTR.AffinitymaybealteredbythepresenceofTrkAreceptors.Neuroprotective.
TechnicalData
M.Wt | 362.34 |
Formula | C19H14N4O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 77422-99-2 |
PubChemID | 9885305 |
InChIKey | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
Smiles | O=C(C4=CC=CC=C4)NC1=CC=C3C(C(N2C(N3C)=CC(C(O)=O)=N2)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 7.25 | 20mMwithsonication |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight362.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.76mL | 13.8mL | 27.6mL |
5mM | 0.55mL | 2.76mL | 5.52mL |
10mM | 0.28mL | 1.38mL | 2.76mL |
50mM | 0.06mL | 0.28mL | 0.55mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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