Tocris信号通路抑制剂 Tocris小分子,Tocris/PF 04217903 mesylate/4239/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PF 04217903 mesylate/4239/50/50 mg

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Tocris/PF 04217903 mesylate/4239/50/50 mg

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Tocris

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4239/50

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4000-520-616

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Description:HighlyselectiveMETinhibitor

ChemicalName:4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanolmesylate

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highlyselective,highaffinityMETinhibitor(K_i=6-7nMagainstwildtypec-Met).Displays>1000-foldselectivityforc-Metoverapanelof208kinases.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	468.49
Formula	C₁₉H₁₆N₈O.CH₃SO₃H
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	956906-93-7
PubChemID	24852079
InChIKey	HBEMHKVWZJTVOC-UHFFFAOYSA-N
Smiles	OCCN1N=CC(C2=CN=C3C(N(CC4=CC=C(N=CC=C5)C5=C4)N=N3)=N2)=C1.CS(=O)(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	46.85	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight468.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.13mL	10.67mL	21.35mL
5mM	0.43mL	2.13mL	4.27mL
10mM	0.21mL	1.07mL	2.13mL
50mM	0.04mL	0.21mL	0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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