BiologicalActivity
HighaffinityandselectiveALKandROS1inhibitor(Kivaluesare<0.02,<0.07and0.7nMforROS1,wild-typeALKandALK-L1196M,respectively).Exhibits>100-foldselectivityforROS1overapanelof204otherkinases.InhibitsproliferationofBaF3cellscontainingcrizotinib-resistantROS1mutationinvitro.Inhibitstumorgrowthinrelevantmousemodels.Orallyavailableandbrainpenetrant.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PF06463922isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 406.41 |
| Formula | C21H19FN6O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1454846-35-5 |
| PubChemID | 71731823 |
| InChIKey | IIXWYSCJSQVBQM-LLVKDONJSA-N |
| Smiles | C[C@@H](O3)C4=C(C=CC(F)=C4)C(N(C)CC1=NN(C)C(C#N)=C1C2=CC3=C(N)N=C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.64 | 100 | |
| ethanol | 40.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight406.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.46mL | 12.3mL | 24.61mL |
| 5mM | 0.49mL | 2.46mL | 4.92mL |
| 10mM | 0.25mL | 1.23mL | 2.46mL |
| 50mM | 0.05mL | 0.25mL | 0.49mL |
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