Tocris试剂产品信息 TOCRIS 4372-10MG,Tocris/PHA 665752/2693/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

商品信息

联系客服

郑重提醒：

无质量问题不接受退换货，下单前请仔细核对信息。

下单后请及时联系客服核对商品价格，订单生效后再付款。

Tocris/PHA 665752/2693/50/50 mg

品牌 /

Tocris

货号 /

2693/50

官网地址

美元价：

登录查看

(友情提示：该价格仅为参考，欢迎联系客服询价！)

数量：

免费咨询热线

4000-520-616

商品介绍售后保障相关文章商品咨询

联系客服

Description:PotentandselectiveMETinhibitor

ChemicalName:(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,selectiveandATP-competitiveinhibitorofMETkinase(IC₅₀valuesare9,68,200,1400,3000,3800and6000nMforMET,Ron,Flk-1,c-abl,FGFR1,EGFRandc-srcrespectivelyand>10000nMforIGF-IR,PDGFR,AURORA2,PKA,PKBα,p38α,MK2andMK3).Antitumoragent;inhibitstumOrigenicityandangiogenesisinmouselungcancerxenografts.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PHA665752isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	641.61
Formula	C₃₂H₃₄Cl₂N₄O₄S
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	477575-56-7
PubChemID	10461815
InChIKey	OYONTEXKYJZFHA-SSHUPFPWSA-N
Smiles	ClC1=C(CS(C2=CC(/C(C(N4)=O)=C/C3=C(C)C(C(N5CCC[C@@H]5CN6CCCC6)=O)=C(C)N3)=C4C=C2)(=O)=O)C(Cl)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	64.16	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight641.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.56mL	7.79mL	15.59mL
5mM	0.31mL	1.56mL	3.12mL
10mM	0.16mL	0.78mL	1.56mL
50mM	0.03mL	0.16mL	0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

Selectanotherlanguage: