BiologicalActivity
Multi-kinaseinhibitor.ExhibitsinhibitoryactivityagainstChk2,KDR,FGFR,AuroraAkinaseandCdk2(IC50valuesare24,34,50,58and88nMrespectively).AlsobindsVEGFR-2,FGFR1andPDGFRβ(Kdvaluesare0.015,0.061and0.088μMrespectively).Displaysantiproliferativeactivityinvitro;inhibitsmitosisandangiogenesis.Orallybioavailable.
CompoundLibraries
R1530isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 356.78 |
| Formula | C18H14ClFN4O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 882531-87-5 |
| PubChemID | 11610113 |
| InChIKey | UOVCGJXDGOGOCZ-UHFFFAOYSA-N |
| Smiles | FC(C(OC)=C1)=CC2=C1NC3=NNC(C)=C3N=C2C4=C(Cl)C=CC=C4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.68 | 100 | |
| ethanol | 35.68 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight356.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.8mL | 14.01mL | 28.03mL |
| 5mM | 0.56mL | 2.8mL | 5.61mL |
| 10mM | 0.28mL | 1.4mL | 2.8mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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