BiologicalActivity
Potentandselectivec-METkinaseinhibitor(IC50=4nM).Exhibitsminimalinhibitionagainstapanelof213otherproteinkinases(at1μM).Suppressesgrowthoftumorxenograftsderivedfromhumanglioblastoma,lungandgastriccancercells.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofSGX523isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 359.41 |
| Formula | C18H13N7S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1022150-57-7 |
| PubChemID | 24779724 |
| InChIKey | BCZUAADEACICHN-UHFFFAOYSA-N |
| Smiles | CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.19 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight359.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.78mL | 13.91mL | 27.82mL |
| 5mM | 0.56mL | 2.78mL | 5.56mL |
| 10mM | 0.28mL | 1.39mL | 2.78mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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