Tocris神经传递素 Tocris多肽,Tocris/SPP 86/5391/10/10 mg,激酶,Tocris,Bio-Techne,,10 mg蚂蚁淘商城

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Tocris/SPP 86/5391/10/10 mg

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Tocris

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5391/10

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4000-520-616

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Description:PotentRETinhibitor

ChemicalName:1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentRETinhibitor(IC₅₀=8nM).AlsoexhibitsinhibitoryactivityatEphA1,FGFR1,Flt4,LckandYes.InhibitsproliferationofHCT116andTPC1cellsinvitro.Cellpermeable.

CompoundLibraries

SPP86isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	277.32
Formula	C₁₆H₁₅N₅
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1357349-91-7
PubChemID	66549796
InChIKey	JQOIRTDBHMDWMT-UHFFFAOYSA-N
Smiles	CC(C)N1N=C(C#CC3=CC=CC=C3)C2=C1N=CN=C2N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	27.73	100
	ethanol	5.55	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight277.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.61mL	18.03mL	36.06mL
5mM	0.72mL	3.61mL	7.21mL
10mM	0.36mL	1.8mL	3.61mL
50mM	0.07mL	0.36mL	0.72mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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